Acosta J. B., del Barco D. G., Vera D. C., Savigne W., Lopez-Saura P., Guillen Nieto G., et al.. (2008). The pro-inflammatory environment in recalcitrant diabetic foot wounds. Int. Wound J. 5, 530–539. 10.1111/j.1742-481X.2008.00457.x [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar] All randomised subjects and who had at least one exposure to the device were included in the intent‐to‐treat (ITT) population. Subjects were analysed in the treatment groups to which they were randomly assigned to avoid bias in the treatment comparisons. The treatment code was determined by the original randomisation. The per protocol (PP) population consisted of all enrolled subjects who satisfied the entry criteria of this study and who completed the treatment as defined in the protocol, without any major protocol violation. Dissemond J. et al. Clinical evaluation of polyabsorbent TLC-NOSF dressings on chronic wounds: a prospective, observational, multicentre study of 1,140 patients. J Wound Care. 2020; 29(6): 350-361.

Lee M., Han S. H., Choi W. J., Chung K., Lee J. W. (2016). Hyaluronic acid dressing ( Healoderm) in the treatment of diabetic foot ulcer: a prospective, randomized, placebo-controlled, single-center study. Wound Repair Regen. 24, 581–588. 10.1111/wrr.12428 [ PubMed] [ CrossRef] [ Google Scholar] A large amount of exudate; prone to infection; severe cases can injure subcutaneous and submucosal tissues Franks P. J., Moody M., Moffatt C. J., Hiskett G., Gatto P., Davies C., et al.. (2007). Randomized trial of two foam dressings in the management of chronic venous ulceration. Wound Repair Regen. 15, 197–202. 10.1111/j.1524-475X.2007.00205.x [ PubMed] [ CrossRef] [ Google Scholar]

AWB.555.10

Guo S., Dipietro L. A. (2010). Factors affecting wound healing. J. Dent. Res. 89, 219–229. 10.1177/0022034509359125 [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar]

The test for the non inferiority of AQUACEL ® Ag to Urgotul ® Silver in area reduction was carried out through a confidence interval (CI) approach. Non inferiority was established if the lower bilateral limit of the 95% CI for the between‐treatment difference (AQUACEL ® Ag – Urgotul ® Silver) in the mean percentage area change from baseline did not exceed −15%. According to previously developed recommendations 26, 27, the non inferiority test was evaluated on both ITT and PP populations. NICE Medical Technology Guidance (MTG242): UrgoStart for treating leg ulcers and diabetic foot ulcers; https://www.nice.org.uk, accessed January 2019. FX. Bernard, F. Juchaux et al., Effets d’un pansement lipido-colloïde sur la production de matrice extracellulaire. Journal des Plaies et Cicatrisations, 2007. (Study conducted on Urgotul). This binding and drainage of slough by the hydro-desloughing structure of UrgoClean Ag combined with its Silver healing matrix (TLC-Ag) thereby promotes the desloughing phase of sloughy wounds, and aids management of minor bleeding (particularly after mechanical or surgical debridement).

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Silver wound dressing that is fast and powerful at killing bacteria, destroys biofilms and prevents reformation. Huang Y., Li X., Liao Z., Zhang G., Liu Q., Tang J., et al.. (2007). A randomized comparative trial between Acticoat and SD-Ag in the treatment of residual burn wounds, including safety analysis. Burns 33, 161–166. 10.1016/j.burns.2006.06.020 [ PubMed] [ CrossRef] [ Google Scholar]

Kamoun E. A., Kenawy E. S., Chen X. (2017). A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings. J. Adv. Res. 8, 217–233. 10.1016/j.jare.2017.01.005 [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar] Hydrogels have a three-dimensional structure composed of hydrophilic substances (Tsang and Bhatia, 2004). They are insoluble in water and subsequently absorb water from 10% to thousands fold their equivalent weight (Goodwin et al., 2016). Owing to their excellent moisturizing ability, hydrogels maintain the wound moist and play a positive role in the cleansing of necrotic tissue. In addition, a wound covered with a dressing can be monitored, as the hydrogels are typically transparent (Hunt, 2003; Scanlon, 2003; Kamoun et al., 2017). Based on these characteristics, hydrogels are primarily used on pressure ulcers, surgical wounds, burns, radiation dermatitis, etc. (Francesko et al., 2017; Shamloo et al., 2018). They are suitable for wounds with minimal-to-moderate exudate. The degradation rate of the hydrogel can also be adjusted, which renders this material appropriate for use as a drug carrier and biologically active substance (Gil et al., 2017). For example, silver nanoparticles (Ag NPs) and ZnO NPs loaded hydrogels can maintain antibacterial activity for a long period of time (Li S. et al., 2018). Recently, a study prepared a multifunctional hydrogel for diabetic wounds. This hydrogel can be used on wounds to collect wound photos via mobile phone and transformed into RGB signals to monitor the pH and glucose levels of diabetic wounds in real time (Zhu et al., 2019). Hydrocolloid and hydrofiber dressings are composed of the same materials in nature. Notably, the latter type is a variant of hydrocolloid dressing appropriate for use as a secondary dressing, which can absorb >25-fold its own weight in fluid while maintaining its integrity (Hobot et al., 2008; Richetta et al., 2011).Hobot J., Walker M., Newman G., Bowler P. (2008). Effect of hydrofiber wound dressings on bacterial ultrastructure. J. Electron Microsc. 57, 67–75. 10.1093/jmicro/dfn002 [ PubMed] [ CrossRef] [ Google Scholar] Cutimed Sorbact gel dressings reduce bacterial load in a wound by combining Cutimed Sorbact swab with an amorphous hydrogel to support moist wound healing in lower exuding or sloughy wounds. Edmonds M., Lazaro-Martinez J. L., Alfayate-Garcia J. M., Martini J. (2018). Sucrose octasulfate dressing versus control dressing in patients with neuroischaemic diabetic foot ulcers (Explorer): an international, multicentre, double-blind, randomised, controlled trial. Lancet Diabetes Endocrinol. 6, 186–196. 10.1016/S2213-8587(17)30438-2 [ PubMed] [ CrossRef] [ Google Scholar] White R. Supporting evidence - based practice: a clinical review of TLC technology, J Wound Care 2015. Barnea Y., Weiss J., Gur E. (2010). A review of the applications of the hydrofiber dressing with silver (Aquacel Ag) in wound care. Ther. Clin. Risk Manage. 6, 21–27. 10.2147/TCRM.S3462 [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar]

Borda L. J., Macquhae F. E., Kirsner R. S. (2016). Wound dressings: a comprehensive review. Curr. Dermatol. Rep. 5, 287–297. 10.1007/s13671-016-0162-5 [ CrossRef] [ Google Scholar]Horn T. (2012). [Wound dressings. Overview and classification]. Unfallchirurg 115, 774–782. 10.1007/s00113-012-2209-9 [ PubMed] [ CrossRef] [ Google Scholar]